<< Back

 Application of macroporous resin adsorption technology in extraction of traditional Chinese Medicine

1、 The basic principle of macroporous resin adsorption technology
The technology of    macroporous adsorption resin is a new technology developed in the 1970s. Simply speaking, it is a purification and refining method that the decoction of traditional Chinese medicine compound is absorbed by macroporous resin, the effective components are recovered by elution, and the impurities are removed.

2、 Advantages of macroporous resin adsorption technology in the application of traditional Chinese Medicine
Extraction and separation of traditional Chinese medicine is the most critical link in the production process of Chinese patent medicine, and also the key problem restricting the improvement of the quality of traditional Chinese medicine, which directly affects the quality of products and clinical efficacy. In the past 30 years, the old extraction technology and equipment of traditional Chinese medicine have been basically used up to now, there is no obvious reform and breakthrough, and the method of water boiling and alcohol precipitation is still very common, which makes the pharmaceutical technology of traditional Chinese medicine in China lag behind the level of international pharmaceutical industry. Crude (more impurities), large (large dosage) and black (dark color) are the main factors restricting the industrialization development of traditional Chinese medicine and expanding the international market. Compared with the traditional methods and processes of impurity removal, macroporous resin adsorption technology has the following three advantages in impurity removal and purification of the extracted solution:
Firstly, it can reduce the dosage and improve the internal quality and preparation level of traditional Chinese medicine. The refined products obtained by macroporous resin adsorption technology can make the effective ingredients highly dense and have few impurities, and the extraction rate is only 2-5% of the original crude drugs, while the general boiling method is about 20-30%, the alcohol precipitation method is about 15%, the dosage is reduced, the impurities are less, and the internal quality is improved, which is conducive to the preparation of modern dosage forms of traditional Chinese medicine, as well as the quality control. Pharmacodynamics and clinical practice have confirmed that the same kind of medicine can improve its efficacy after using this technology, which has completed two processes of impurity removal and concentration once. For example, ginsenosides are also contained in the stems and leaves of Panax ginseng, which can be extracted for medicinal use, but the content is low, so it is difficult to extract them by general methods, and the content of ginsenosides can reach more than 70% after purification by macroporous resin adsorption technology, so it is very convenient to extract. For example, the volume of decoction extract of traditional Chinese medicine is large, the content of effective components is low, the dosage is too large, and it is difficult to choose the dosage form, which brings difficulties to the production. If macroporous resin adsorption technology is used, the problems will be solved.
Second, reduce the moisture absorption of the product. Most of the Chinese patent medicines prepared by traditional technology have strong hygroscopicity, which is a long-term problem in the production and storage of traditional Chinese medicine. After the treatment of macroporous resin adsorption technology, it can effectively remove a large number of hygroscopic components such as sugar, inorganic salt, mucus in the decoction, which is conducive to the production of a variety of traditional Chinese medicine dosage forms and enhance the stability of products.
Thirdly, macroporous resin adsorption technology can shorten the production cycle, require simple equipment, avoid time-consuming work such as static precipitation and concentration, save packaging, reduce costs, and create conditions for traditional Chinese medicine to enter the international market.
                    
3.It is confirmed by pharmacodynamic test and clinical observation that a set of mature process can not only ensure the efficacy, but also improve the efficacy after purification. However, there are many technical problems in the application, such as the selection of resin model. The specifications and quality requirements of the resin itself play a decisive role in the purification effect and safety of the extract of traditional Chinese medicine. It is not suitable to use a type of resin to refine and purify the water extract of traditional Chinese medicine. In the process of purification and purification, we must select the pharmacodynamic experimental method related to the efficacy according to the needs of the treatment of the disease, and track the effective chemical components of the medicine, so as to ensure that the effective components are not lost and the efficacy is not reduced in the purification and purification process, The quality is stable and reliable. In order to ensure the quality of drugs, the best technological conditions must be selected first, such as the amount of resin, the maximum amount of adsorption, the speed of adsorption and elution, the height and diameter of resin column, the kind and concentration of elution solution, etc.

4、 Problems in application of macroporous resin adsorption technology. Before use, the pore forming agent is not completely removed. In the long-term use, whether the resin will degrade will cause the pollution of toxic substances and other problems. However, after many tests, we have found out the treatment methods of pore formers and degradation products before using the resin, formed a complete set of detection methods, formulated quality control standards for benzene, toluene, etc., and passed the review of the State Drug Administration. As for the problem of secondary pollution caused by liquid medicine residues, it is rare in large manufacturers. Because in large-scale production, one resin only aims at the purification and refinement of one drug, and it is impossible for one resin to adsorb several drugs. People always have to selectively retain the effective ingredients according to the ingredients of each drug, so it is one-to-one correspondence, and the problem of adsorption capacity has attracted extensive attention, but as long as the detection of the index ingredients in the liquid medicine before and after the column is often carried out, the adsorption capacity is lower It can be solved by processing or replacing new resin in time.
Application prospect of macroporous resin adsorption technology

It is easy to make various dosage forms with beautiful appearance, especially suitable for granule, Xiangxiang and tablet, and upgrade the crude, large and black preparations of traditional Chinese medicine to modern preparations. As far as macroporous resin technology itself is concerned, its operation is simple, not very tedious, and the difficulty is not great, and the resin can be used many times or repeatedly, the cost is not very high, the equipment is simple, and this technology can save a lot of energy consumption, auxiliary materials, packaging materials, storage, transportation and other costs. At present, macroporous resin adsorption technology is widely used in the production of Western medicine. In China, more and more enterprises are exploring the application of macroporous resin adsorption technology in the research and production of traditional Chinese medicine, such as Chengdu Di'ao Pharmaceutical Co., Ltd. Yangzijiang Pharmaceutical Group also uses this technology to produce Ginkgo biloba preparation. It is widely used by western medicine manufacturers in Beijing. Tongrentang pharmaceutical factory is also using this technology. It can be seen that the application prospect of macroporous resin adsorption technology is very broad.